PABPC1 Antibody
Product Specifications
Background
PABPC1 binds the poly (A) tail of mRNA. It may be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre-mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. PABPC1 can probably bind to cytoplasmic RNA sequences other than poly (A) in vivo. It may be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.
NCBI Gene ID
26986
Swiss Prot
P11940
Accession Number
P11940
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This PABPC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 250-279 amino acids from the Central region of human PABPC1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Rat, Xenopus
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=61-598
Calculated Molecular Weight
71 kDa
Fragment
Rabbit Ig
Symbol
PABPC1
NCBI Official Name
Polyadenylate-binding protein 1
NCBI Organism
Homo sapiens
Background Reference 01
Le Clerc, S., et.al., J. Infect. Dis. 200 (8), 1194-1201 (2009)
Other Product Names
Polyadenylate-binding protein 1, PABP-1, Poly (A) -binding protein 1, PABPC1, PAB1, PABP1, PABPC2
Tested Applications
WB, IHC-P
Protein ID
3183544
Physical Properties
Liquid
Curated Selection
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