ELP2 Antibody

Product Specifications

Background

ELP2 regulates the ligand-dependent activation of STAT3. The protein acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4.

NCBI Gene ID

55250

Swiss Prot

Q6IA86

Accession Number

Q6IA86

Host

Rabbit

Reactivity

Human

Immunogen

This ELP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 737-765 amino acids from the C-terminal region of human ELP2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

93 kDa

Fragment

Rabbit Ig

Symbol

ELP2

NCBI Official Name

Elongator complex protein 2

NCBI Organism

Homo sapiens

Background Reference 01

References for protein:

Background Reference 02

Kim, J.H., Proc. Natl. Acad. Sci. U.S.A. 99 (3), 1241-1246 (2002)

Background Reference 03

Hawkes, N.A., J. Biol. Chem. 277 (4), 3047-3052 (2002)

Background Reference 04

References for SY5Y (SH-SY5Y; ATCCCRL-2266) : 1. Ross RA, et al. Coordinate morphological and biochemical interconversion of human neuroblastoma cells. J. Natl. Cancer Inst. 71: 741-749, 1983. [PubMed: 6137586]; 2. Biedler JL, et al. Multiple neurotransmitter synthesis by human neuroblastoma cell lines and clones. Cancer Res. 38: 3751-3757, 1978. [PubMed: 29704].