CD105 Antibody
Product Specifications
Background
CD105 is a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds TGFB1 and TGFB3 with high affinity. Mutations in its gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia.
NCBI Gene ID
2022
Swiss Prot
P17813
Accession Number
P17813
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This CD105 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 380-409 amino acids from the Central region of human CD105.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Immunology, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
71 kDa
Fragment
Rabbit Ig
Symbol
ENG
NCBI Official Name
Endoglin
NCBI Organism
Homo sapiens
Background Reference 01
Chen, Y., Ann. Neurol. 66 (1), 19-27 (2009)
Background Reference 02
Rius, C., Blood 92 (12), 4677-4690 (1998)
Other Product Names
Endoglin, CD105, ENG, END
Tested Applications
WB, IHC-P, Flow
Protein ID
3041681
Physical Properties
Liquid
Curated Selection
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