APEX1 Antibody
Product Specifications
Background
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This protein is the major AP endonuclease in human cells.
NCBI Gene ID
328
Swiss Prot
P27695
Accession Number
P27695
Host
Rabbit
Reactivity
Human
Immunogen
This APEX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 30-64 amino acids from the N-terminal region of human APEX1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
36 kDa
Fragment
Rabbit Ig
Symbol
APEX1
NCBI Official Name
DNA- (apurinic or apyrimidinic site) lyase
NCBI Organism
Homo sapiens
Background Reference 01
Vascotto, C., Mol. Cell. Biol. 29 (7), 1834-1854 (2009)
Background Reference 02
Li, W.Q., Carcinogenesis 30 (3), 500-505 (2009)
Background Reference 03
Lo, Y.L., Cancer Epidemiol. Biomarkers Prev. 18 (1), 223-229 (2009)
Background Reference 04
Bhakat, K.K., EMBO J. 22 (23), 6299-6309 (2003)
Other Product Names
DNA- (apurinic or apyrimidinic site) lyase, 31--, APEX nuclease, APEN, Apurinic-apyrimidinic endonuclease 1, AP endonuclease 1, APE-1, REF-1, Redox factor-1, DNA- (apurinic or apyrimidinic site) lyase, mitochondrial, APEX1, APE, APE1, APEX, APX, HAP1, REF1
Tested Applications
WB, IF
Protein ID
113984
Physical Properties
Liquid
Frequently Asked Questions
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