INPP5D Antibody
Product Specifications
Background
INPP5D is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and it is a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5) -trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival.
NCBI Gene ID
3635
Swiss Prot
Q92835
Accession Number
Q92835
Host
Rabbit
Reactivity
Human
Immunogen
This INPP5D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 770-796 amino acids from the Central region of human INPP5D.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
133 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
INPP5D
NCBI Official Name
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
NCBI Organism
Homo sapiens
Background Reference 01
Gilby, D.C., Leukemia 21 (11), 2390-2393 (2007)
Background Reference 02
Gloire, G., Biochem. Soc. Trans. 35 (PT 2), 277-280 (2007)
Background Reference 03
Vaillancourt, M., Cell. Signal. 18 (11), 2022-2032 (2006)
Other Product Names
Phosphatidylinositol 3,5-trisphosphate 5-phosphatase 1, Inositol polyphosphate-5-phosphatase of 145 kDa, SIP-145, SH2 domain-containing inositol 5'-phosphatase 1, SH2 domain-containing inositol phosphatase 1, SHIP-1, p150Ship, hp51CN, INPP5D, SHIP, SHIP1
Tested Applications
WB
Protein ID
158564077
Physical Properties
Liquid
Curated Selection
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