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INPP5D Antibody

Product Specifications

Background

INPP5D is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and it is a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5) -trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival.

NCBI Gene ID

3635

Swiss Prot

Q92835

Accession Number

Q92835

Host

Rabbit

Reactivity

Human

Immunogen

This INPP5D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 770-796 amino acids from the Central region of human INPP5D.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=61-547

Calculated Molecular Weight

133 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

INPP5D

NCBI Official Name

Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

NCBI Organism

Homo sapiens

Background Reference 01

Gilby, D.C., Leukemia 21 (11), 2390-2393 (2007)

Background Reference 02

Gloire, G., Biochem. Soc. Trans. 35 (PT 2), 277-280 (2007)

Background Reference 03

Vaillancourt, M., Cell. Signal. 18 (11), 2022-2032 (2006)

Other Product Names

Phosphatidylinositol 3,5-trisphosphate 5-phosphatase 1, Inositol polyphosphate-5-phosphatase of 145 kDa, SIP-145, SH2 domain-containing inositol 5'-phosphatase 1, SH2 domain-containing inositol phosphatase 1, SHIP-1, p150Ship, hp51CN, INPP5D, SHIP, SHIP1

Tested Applications

WB

Protein ID

158564077

Physical Properties

Liquid

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