DHCR24 Antibody
Product Specifications
Background
DHCR24 is a flavin adenine dinucleotide (FAD) -dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. This protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of its gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.
NCBI Gene ID
1718
Swiss Prot
Q15392
Accession Number
Q15392
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This DHCR24 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 57-87 amino acids from the N-terminal region of human DHCR24.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Obesity, Neuroscience
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Monkey
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=61-540
Calculated Molecular Weight
60 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
DHCR24
NCBI Official Name
Delta (24) -sterol reductase
NCBI Organism
Homo sapiens
Background Reference 01
Wang, Y., Mol. Pharmacol. 74 (6), 1716-1721 (2008)
Background Reference 02
Bonaccorsi, L., Lab. Invest. 88 (10), 1049-1056 (2008)
Background Reference 03
Cecchi, C., J. Cell. Mol. Med. 12 (5B), 1990-2002 (2008)
Other Product Names
Delta (24) -sterol reductase, 24-dehydrocholesterol reductase, 3-beta-hydroxysterol delta-24-reductase, Diminuto/dwarf1 homolog, Seladin-1, DHCR24, KIAA0018
Tested Applications
WB
Protein ID
20141421
Physical Properties
Liquid
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