POLR1C Antibody

Product Specifications

Background

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft.

NCBI Gene ID

9533

Swiss Prot

O15160

Accession Number

O15160

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This POLR1C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 319-346 amino acids from the C-terminal region of human POLR1C.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

39 kDa

Fragment

Rabbit Ig

Symbol

POLR1C

NCBI Official Name

DNA-directed RNA polymerases I and III subunit RPAC1

NCBI Organism

Homo sapiens

Background Reference 01

Rush, J., Nat. Biotechnol. 23 (1), 94-101 (2005)

Background Reference 02

Hirschler-Laszkiewicz, I., J. Biol. Chem. 278 (21), 18953-18959 (2003)

Background Reference 03

Dammann, R., Biochim. Biophys. Acta 1396 (2), 153-157 (1998)

Background Reference 04

Seither, P., Chromosoma 106 (4), 216-225 (1997)

Other Product Names

DNA-directed RNA polymerases I and III subunit RPAC1, DNA-directed RNA polymerase I subunit C, RNA polymerases I and III subunit AC1, AC40, DNA-directed RNA polymerases I and III 40 kDa polypeptide, RPA40, RPA39, RPC40, POLR1C, POLR1E