POLG2 Antibody

Product Specifications

Background

The accuracy of mitochondrial DNA (mtDNA) replication depends on the coordinated action of many nuclear-encoded proteins and on the correct balance of nucleotides within the mitochondrial matrix. mtDNA is replicated by DNA polymerase gamma, which is composed of a 140-kD catalytic subunit (POLG1) and a 55-kD accessory subunit (POLG2) .

NCBI Gene ID

11232

Swiss Prot

Q9UHN1

Accession Number

Q9UHN1

Host

Rabbit

Reactivity

Human

Immunogen

This POLG2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 348-376 amino acids from the C-terminal region of human POLG2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

55 kDa

Fragment

Rabbit Ig

Symbol

POLG2

NCBI Official Name

DNA polymerase subunit gamma-2, mitochondrial

NCBI Organism

Homo sapiens

Background Reference 01

Longley, M.J., Am. J. Hum. Genet. 78 (6), 1026-1034 (2006)

Background Reference 02

Carrodeguas, J.A., J. Biol. Chem. 277 (51), 50008-50014 (2002)

Other Product Names

DNA polymerase subunit gamma-2, mitochondrial, DNA polymerase gamma accessory 55 kDa subunit, p55, Mitochondrial DNA polymerase accessory subunit, MtPolB, PolG-beta, POLG2, MTPOLB