PCNA Antibody
Product Specifications
Background
PCNA is found in the nucleus and is a cofactor of DNA polymerase delta. This protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway.
NCBI Gene ID
5111
Swiss Prot
P12004
Accession Number
P12004
Host
Rabbit
Reactivity
Human
Immunogen
This PCNA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 89-117 amino acids from the Central region of human PCNA.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Chicken, Hamster, Monkey, Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
29 kDa
Fragment
Rabbit Ig
Symbol
PCNA
NCBI Official Name
Proliferating cell nuclear antigen
NCBI Organism
Homo sapiens
Background Reference 01
Wang, Y., J. Cell. Biochem. 106 (3), 409-413 (2009)
Background Reference 02
Maga, G., Proc. Natl. Acad. Sci. U.S.A. 105 (52), 20689-20694 (2008)
Background Reference 03
Acharya, N., Proc. Natl. Acad. Sci. U.S.A. 105 (46), 17724-17729 (2008)
Other Product Names
Proliferating cell nuclear antigen, PCNA, Cyclin, PCNA
Tested Applications
WB, IHC-P, IF, Flow
Protein ID
129694
Physical Properties
Liquid
Frequently Asked Questions
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