NPM1 Antibody

Product Specifications

Background

NPM1 is a ubiquitously expressed nucleolar protein that shuttles between the nucleus and cytoplasm. It is implicated in multiple functions, including ribosomal protein assembly and transport, control of centrosome duplication, and regulation of the tumor suppressor ARF. NPM1 mutations that relocalize NPM1 from the nucleus into the cytoplasm are associated with development of acute myeloid leukemia.

NCBI Gene ID

4869

Swiss Prot

P06748

Accession Number

P06748

Host

Rabbit

Reactivity

Human

Immunogen

This NPM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 198-226 amino acids from the C-terminal region of human NPM1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

33 kDa

Fragment

Rabbit Ig

Symbol

NPM1

NCBI Official Name

Nucleophosmin

NCBI Organism

Homo sapiens

Background Reference 01

Vascotto, C., Mol. Cell. Biol. 29 (7), 1834-1854 (2009) Ma, W., Cancer Biomark (1), 51-58 (2009) Zhang, H., J. Biol. Chem. 279 (34), 35726-35734 (2004)