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GADD45A Antibody

Product Specifications

Background

GADD45A responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45A gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms.

NCBI Gene ID

1647

Swiss Prot

P24522

Accession Number

P24522

Host

Rabbit

Reactivity

Human

Immunogen

This GADD45A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 133-165 amino acids from the C-terminal region of human GADD45A.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Rat, Hamster, Bovine

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=61-503

Calculated Molecular Weight

18 kDa

Fragment

Rabbit Ig

Symbol

GADD45A

NCBI Official Name

Growth arrest and DNA damage-inducible protein GADD45 alpha

NCBI Organism

Homo sapiens

Background Reference 01

Li, L.S., J. Biol. Chem. 283 (31), 21394-21403 (2008)

Background Reference 02

Al-Romaih, K., Neoplasia 10 (5), 471-480 (2008)

Background Reference 03

Zhu, Q.S., Cancer Res. 68 (8), 2895-2903 (2008)

Background Reference 04

Kearsey, J.M., Oncogene 11 (9), 1675-1683 (1995)

Other Product Names

Growth arrest and DNA damage-inducible protein GADD45 alpha, DNA damage-inducible transcript 1 protein, DDIT-1, GADD45A, DDIT1, GADD45

Tested Applications

WB, Flow

Protein ID

120751

Physical Properties

Liquid

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