EXOSC8 Antibody

Product Specifications

Background

EXOSC8 is a component of the exosome 3'->5' exoribonuclease complex, a complex that degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3'-untranslated regions. It is required for the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA and has a 3'-5' exonuclease activity.

NCBI Gene ID

11340

Swiss Prot

Q96B26

Accession Number

Q96B26

Host

Rabbit

Reactivity

Human

Immunogen

This EXOSC8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 243-276 amino acids from the C-terminal region of human EXOSC8.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

30 kDa

Fragment

Rabbit Ig

Symbol

EXOSC8

NCBI Official Name

Exosome complex component RRP43

NCBI Organism

Homo sapiens

Background Reference 01

Raijmakers, R., J. Mol. Biol. 323 (4), 653-663 (2002)

Background Reference 02

Jiang, T., Proc. Natl. Acad. Sci. U.S.A. 99 (8), 5295-5300 (2002)

Background Reference 03

Raijmakers, R., J. Mol. Biol. 315 (4), 809-818 (2002)

Background Reference 04

Brouwer, R., J. Biol. Chem. 276 (9), 6177-6184 (2001)

Other Product Names

Exosome complex component RRP43, Exosome component 8, Opa-interacting protein 2, OIP-2, Ribosomal RNA-processing protein 43, p9, EXOSC8, OIP2, RRP43

Tested Applications

WB, IHC-P, Flow

Protein ID

21759409

Physical Properties

Liquid

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