HNF4A Antibody

Product Specifications

Background

HNF4A is a nuclear transcription factor which binds DNA as a homodimer. This protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This protein may play a role in development of the liver, kidney, and intestines. Mutations in this protein have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I.

NCBI Gene ID

3172

Swiss Prot

P41235

Accession Number

P41235

Host

Rabbit

Reactivity

Human

Immunogen

This HNF4A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 118-146 amino acids from human HNF4A.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Cell Cycle, Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Rat, Xenopus

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

53 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

HNF4A

NCBI Official Name

Hepatocyte nuclear factor 4-alpha

NCBI Organism

Homo sapiens

Background Reference 01

Sugai, M., Pathol. Int. 58 (11), 681-686 (2008)

Background Reference 02

Lee, S.S., Hepatology 48 (2), 635-645 (2008)

Background Reference 03

Guo, H., Biochem. J. 394 (PT 2), 379-387 (2006)

Background Reference 04

Hong, Y.H., J. Biol. Chem. 278 (30), 27495-27501 (2003)

Other Product Names

Hepatocyte nuclear factor 4-alpha, HNF-4-alpha, Nuclear receptor subfamily 2 group A member 1, Transcription factor 14, TCF-14, Transcription factor HNF-4, HNF4A, HNF4, NR2A1, TCF14