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DAAM1 Antibody

Product Specifications

Background

Functions of the cell cortex, including motility, adhesion, and cytokinesis, are mediated by the reorganization of the actin cytoskeleton. Recent evidence suggests a role for the Formin homology (FH) proteins in these processes. DAAM1 contains FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. Wnt/Fz signaling activates the small GTPase Rho, a key regulator of cytoskeleton architecture, to control cell polarity and movement during development. Activation requires Dvl-Rho complex formation, an assembly mediated by DAAM1, which is thought to function as a scaffolding protein.

NCBI Gene ID

23002

Swiss Prot

Q9Y4D1

Accession Number

Q9Y4D1

Host

Rabbit

Reactivity

Human

Immunogen

This DAAM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 45-74 amino acids from the N-terminal region of human DAAM1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=61-449

Calculated Molecular Weight

123 kDa

Fragment

Rabbit Ig

Symbol

DAAM1

NCBI Official Name

Disheveled-associated activator of morphogenesis 1

NCBI Organism

Homo sapiens

Background Reference 01

Liu, W., Proc. Natl. Acad. Sci. U.S.A. 105 (1), 210-215 (2008)

Background Reference 02

Yamashita, M., Genes Cells 12 (11), 1255-1265 (2007)

Background Reference 03

Lu, J., J. Mol. Biol. 369 (5), 1258-1269 (2007)

Other Product Names

Disheveled-associated activator of morphogenesis 1, DAAM1, KIAA0666

Tested Applications

WB, IHC-P

Protein ID

34098767

Physical Properties

Liquid

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