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SMC2 Antibody

Product Specifications

Background

SMC2 is a central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

NCBI Gene ID

10592

Swiss Prot

O95347

Accession Number

O95347

Host

Rabbit

Reactivity

Human

Immunogen

This SMC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1166-1197 amino acids from the C-terminal region of human SMC2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=61-428

Calculated Molecular Weight

136 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

SMC2

NCBI Official Name

Structural maintenance of chromosomes protein 2

NCBI Organism

Homo sapiens

Background Reference 01

Schmiesing, J.A., Proc. Natl. Acad. Sci. U.S.A. 95 (22), 12906-12911 (1998)

Background Reference 02

Ham, M.F., Cancer Sci. 98 (7), 1041-1047 (2007)

Other Product Names

Structural maintenance of chromosomes protein 2, SMC protein 2, SMC-2, Chromosome-associated protein E, hCAP-E, XCAP-E homolog, SMC2, CAPE, SMC2L1

Tested Applications

WB

Physical Properties

Liquid

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