CPT1A Antibody
Product Specifications
Background
The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation.
NCBI Gene ID
1374
Swiss Prot
P50416
Accession Number
P50416
Host
Rabbit
Reactivity
Bovine, Human
Immunogen
This CPT1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 606-636 amino acids from the C-terminal region of human CPT1A.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
88 kDa
Fragment
Rabbit Ig
Symbol
CPT1A
NCBI Official Name
Carnitine O-palmitoyltransferase 1, liver isoform
NCBI Organism
Homo sapiens
Background Reference 01
Rasmussen, B.B., et al., J. Clin. Invest. 110 (11) :1687-1693 (2002) .
Background Reference 02
Ogawa, E., et al., J. Hum. Genet. 47 (7) :342-347 (2002) .
Background Reference 03
Cook, G.A., et al., Am. J. Med. Sci. 318 (1) :43-48 (1999) .
Background Reference 04
IJlst, L., et al., J. Clin. Invest. 102 (3) :527-531 (1998) .
Other Product Names
Carnitine O-palmitoyltransferase 1, liver isoform, CPT1-L, Carnitine O-palmitoyltransferase I, liver isoform, CPT I, CPTI-L, Carnitine palmitoyltransferase 1A, CPT1A, CPT1
Tested Applications
WB, IHC-P
Protein ID
56405343
Physical Properties
Liquid
Frequently Asked Questions
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