BMI1 Antibody
Product Specifications
Background
BMI is a component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin ligase activity of RNF2/RING2. BMI cooperates with the MYC oncogene to produce B-lymphomas.
NCBI Gene ID
100532731648
Swiss Prot
P35226
Accession Number
P35226
Host
Rabbit
Reactivity
Human
Immunogen
This BMI1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 257-286 amino acids from the C-terminal region of human BMI1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Chicken, Bovine
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=61-406
Calculated Molecular Weight
37 kDa
Fragment
Rabbit Ig
Symbol
BMI1
NCBI Official Name
Polycomb complex protein BMI-1
NCBI Organism
Homo sapiens
Background Reference 01
Smith, K.S., et al., Mol. Cell 12 (2) :393-400 (2003) . Xia, Z.B., et al., Proc. Natl. Acad. Sci. U.S.A. 100 (14) :8342-8347 (2003) . Itahana, K., et al., Mol. Cell. Biol. 23 (1) :389-401 (2003) . Dimri, G.P., et al., Cancer Res. 62 (16) :4736-4745 (2002) . Bardos, J.I., et al., J. Biol. Chem. 275 (37) :28785-28792 (2000) .
Other Product Names
Polycomb complex protein BMI-1, Polycomb group RING finger protein 4, RING finger protein 51, BMI1, PCGF4, RNF51
Tested Applications
WB, IHC-P
Protein ID
22258801
Physical Properties
Liquid
Curated Selection
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