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P53 Antibody

Product Specifications

Background

Tumor protein p53, a nuclear protein, plays an essential role in the regulation of cell cycle, specifically in the transition from G0 to G1. It is found in very low levels in normal cells, however, in a variety of transformed cell lines, it is expressed in high amounts, and believed to contribute to transformation and malignancy. P53 is subject to modification by conjugation of SUMO-1. A p53 mutant deficient for MDM2 binding is poorly sumoylated in vivo compared to wild-type p53. Overexpression of MDM2 increases the level of p53 sumoylation, which is further stimulated by expression of ARF. These results show that p53 sumoylation is regulated by MDM2- and ARF-mediated nucleolar targeting.

NCBI Gene ID

7157

Swiss Prot

P04637

Accession Number

P04637

Host

Rabbit

Reactivity

Human

Immunogen

This p53 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 364-393 amino acids from human p53.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=61-402

Calculated Molecular Weight

44 kDa

Fragment

Rabbit Ig

Symbol

TP53

NCBI Official Name

Cellular tumor antigen p53

NCBI Organism

Homo sapiens

Background Reference 01

Chen L, et al. Oncogene. 2003 Aug 14;22 (34) :5348-57.

Background Reference 02

Melchior F, et al. Cell Cycle. 2002 Jul-Aug;1 (4) :245-9.

Background Reference 03

Kahyo T, et al. Mol Cell. 2001 Sep;8 (3) :713-8.

Background Reference 04

Kwek SS, et al. Oncogene. 2001 May 3;20 (20) :2587-99.

Other Product Names

Cellular tumor antigen p53, Antigen NY-CO-13, Phosphoprotein p53, Tumor suppressor p53, TP53, P53

Tested Applications

WB, IHC-P

Protein ID

269849759

Physical Properties

Liquid

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