GPI8 Antibody

Product Specifications

Background

GPI8 is a member of the cysteine protease family C13 that is involved in glycosylphosphatidylinositol (GPI) -anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is a member of the multisubunit enzyme, GPI transamidase and is thought to be its enzymatic component. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins.

NCBI Gene ID

10026

Swiss Prot

Q92643

Accession Number

Q92643

Host

Rabbit

Reactivity

Human

Immunogen

This GPI8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37-68 amino acids from the N-terminal region of human GPI8.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Pig

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

45 kDa

Fragment

Rabbit Ig

Symbol

PIGK

NCBI Official Name

GPI-anchor transamidase

NCBI Organism

Homo sapiens

Background Reference 01

Ohishi, K., et al., J. Biol. Chem. 278 (16) :13959-13967 (2003) . Vainauskas, S., et al., J. Biol. Chem. 277 (34) :30535-30542 (2002) . Ohishi, K., et al., EMBO J. 20 (15) :4088-4098 (2001) . Meyer, U., et al., Biochemistry 39 (12) :3461-3471 (2000) . Yu, J., et al., Proc. Natl. Acad. Sci. U.S.A. 94 (23) :12580-12585 (1997) .