FDPS Antibody
Product Specifications
Background
The isoprene biosynthetic pathway supply the cell with cholesterol, ubiquinone, and various nonsterol metabolites. The farnesylpyrophosphate synthetase enzyme catalyzes the formation of geranyl and farnesylpyrophosphate from isopentenylpyrophosphate and dimethylallyl pyrophosphate. Analysis of FDPS activity and protein in rat liver, accompanied by immunofluorescence and immunoelectron microscopy studies, demonstrated that FDPS is predominantly localized in peroxisomes.1 Liver tissue from patients with the peroxisomal deficiency diseases Zellweger syndrome and neonatal adrenoleukodystrophy exhibit diminished activities of FDPS and subsequent isoprenoid synthesis.
NCBI Gene ID
2224
Swiss Prot
P14324
Accession Number
P14324
Host
Rabbit
Reactivity
Human
Immunogen
This FDPS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 82-112 amino acids from the N-terminal region of human FDPS.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=61-389
Calculated Molecular Weight
48 kDa
Fragment
Rabbit Ig
Symbol
FDPS
NCBI Official Name
Farnesyl pyrophosphate synthase
NCBI Organism
Homo sapiens
Background Reference 01
Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99 (26) :16899-16903 (2002) .
Background Reference 02
Nomura, N., et al., DNA Res. 1 (1) :27-35 (1994) .
Background Reference 03
Wilkin, D.J., et al., J. Biol. Chem. 265 (8) :4607-4614 (1990) .
Background Reference 04
Sheares, B.T., et al., Biochemistry 28 (20) :8129-8135 (1989) .
Other Product Names
Farnesyl pyrophosphate synthase, FPP synthase, FPS, (2E,6E) -farnesyl diphosphate synthase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Geranyltranstransferase, FDPS, FPS, KIAA1293
Tested Applications
WB, IHC-P, IF
Protein ID
215274250
Physical Properties
Liquid
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