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COPS7B Antibody

Product Specifications

Background

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

NCBI Gene ID

64708

Swiss Prot

Q9H9Q2

Accession Number

Q9H9Q2

Host

Rabbit

Reactivity

Human

Immunogen

This COPS7B antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 61-95 amino acids from human COPS7B.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=61-356

Calculated Molecular Weight

30 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:2000

Symbol

COPS7B

NCBI Official Name

COP9 signalosome complex subunit 7b

NCBI Organism

Homo sapiens

Background Reference 01

Ota T., et al.Nat. Genet. 36:40-45 (2004) .

Background Reference 02

Hillier L.W., et al.Nature 434:724-731 (2005) .

Background Reference 03

Mural R.J., et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

Background Reference 04

Bech-Otschir D., et al.EMBO J. 20:1630-1639 (2001) .

Other Product Names

COP9 signalosome complex subunit 7b, SGN7b, Signalosome subunit 7b, JAB1-containing signalosome subunit 7b, COPS7B, CSN7B

Tested Applications

WB

Protein ID

55976598

Physical Properties

Liquid

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