TXNRD1 Antibody

Product Specifications

Background

Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.

NCBI Gene ID

7296

Swiss Prot

Q16881

Accession Number

Q16881

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This TXNRD1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 516-550 amino acids from human TXNRD1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Pig, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

71 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:2000

Symbol

TXNRD1

NCBI Official Name

Thioredoxin reductase 1, cytoplasmic

NCBI Organism

Homo sapiens

Background Reference 01

Gasdaska P.Y., et al.FEBS Lett. 373:5-9 (1995) .

Background Reference 02

Koishi R., et al.J. Biol. Chem. 272:2570-2577 (1997) .

Background Reference 03

Hofman E.R., et al.Mol. Cell. Biol. 18:6493-6504 (1998) .

Background Reference 04

Rundloef A.-K., et al.Free Radic. Biol. Med. 36:641-656 (2004) .

Other Product Names

Thioredoxin reductase 1, cytoplasmic, TR, 1.8.1.9, Gene associated with retinoic and interferon-induced mortality 12 protein, GRIM-12, Gene associated with retinoic and IFN-induced mortality 12 protein, KM-102-derived reductase-like factor, Thioredoxin reductase TR1, TXNRD1, GRIM12, KDRF