TIGIT Antibody

Product Specifications

Background

Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.

NCBI Gene ID

201633

Swiss Prot

Q495A1

Accession Number

Q495A1

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This TIGIT antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 12-142 amino acids from human TIGIT.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

26 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:2000

Symbol

TIGIT

NCBI Official Name

T-cell immunoreceptor with Ig and ITIM domains

NCBI Organism

Homo sapiens

Background Reference 01

Ota T., et al.Nat. Genet. 36:40-45 (2004) .

Background Reference 02

Bechtel S., et al.BMC Genomics 8:399-399 (2007) .

Background Reference 03

Yu X., et al.Nat. Immunol. 10:48-57 (2009) .

Background Reference 04

Stengel K.F., et al.Proc. Natl. Acad. Sci. U.S.A. 109:5399-5404 (2012) .

Other Product Names

T-cell immunoreceptor with Ig and ITIM domains, V-set and immunoglobulin domain-containing protein 9, V-set and transmembrane domain-containing protein 3, TIGIT, VSIG9, VSTM3