MLL3 Antibody
Product Specifications
Background
Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder.
NCBI Gene ID
58508
Swiss Prot
Q8NEZ4
Accession Number
Q8NEZ4
Host
Rabbit
Reactivity
Human
Immunogen
This MLL3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1142-1175 amino acids from the N-terminal region of human MLL3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=61-300
Calculated Molecular Weight
541 kDa
Fragment
Rabbit Ig
Applications Notes
For IHC-P starting dilution is: 1:25
Symbol
KMT2C
NCBI Official Name
Histone-lysine N-methyltransferase 2C
NCBI Organism
Homo sapiens
Background Reference 01
Ruault M., et al.Gene 284:73-81 (2002) .
Background Reference 02
Tan Y.C., et al.Cancer Detect. Prev. 25:454-469 (2001) .
Background Reference 03
Hillier L.W., et al.Nature 424:157-164 (2003) .
Background Reference 04
Nagase T., et al.DNA Res. 7:143-150 (2000) .
Other Product Names
Histone-lysine N-methyltransferase 2C, Lysine N-methyltransferase 2C, 2.1.1.43, Homologous to ALR protein, Myeloid/lymphoid or mixed-lineage leukemia protein 3, KMT2C, HALR, KIAA1506, MLL3
Tested Applications
IHC-P
Protein ID
221222521
Physical Properties
Liquid
Curated Selection
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