APIP Antibody
Product Specifications
Background
Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) . Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.
NCBI Gene ID
51074
Swiss Prot
Q96GX9
Accession Number
Q96GX9
Host
Rabbit
Reactivity
Human
Immunogen
This APIP antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 111-142 amino acids from the Central region of human APIP.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=61-295
Calculated Molecular Weight
27 kDa
Fragment
Rabbit Ig
Symbol
APIP
NCBI Official Name
Methylthioribulose-1-phosphate dehydratase {ECO:0000255|HAMAP-Rule:MF_03116}
NCBI Organism
Homo sapiens
Background Reference 01
Lai C.-H., et al.Genome Res. 10:703-713 (2000) .
Background Reference 02
Ota T., et al.Nat. Genet. 36:40-45 (2004) .
Background Reference 03
Taylor T.D., et al.Nature 440:497-500 (2006) .
Background Reference 04
Cho D.-H., et al.J. Biol. Chem. 279:39942-39950 (2004) .
Other Product Names
Methylthioribulose-1-phosphate dehydratase {ECO:0000255|HAMAP-Rule:MF_03116}, MTRu-1-P dehydratase {ECO:0000255|HAMAP-Rule:MF_03116}, 4.2.1.109 {ECO:0000255|HAMAP-Rule:MF_03116}, APAF1-interacting protein {ECO:0000255|HAMAP-Rule:MF_03116}, hAPIP, APIP {ECO:0000255|HAMAP-Rule:MF_03116}
Tested Applications
WB, IHC-P
Protein ID
74731866
Physical Properties
Liquid
Curated Selection
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