SH3PXD2B Antibody

Product Specifications

Background

Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity) .

NCBI Gene ID

285590

Swiss Prot

A1X283

Accession Number

A1X283

Host

Rabbit

Reactivity

Human

Immunogen

This SH3PXD2B antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 596-628 amino acids from human SH3PXD2B.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

102 kDa

Fragment

Rabbit Ig

Symbol

SH3PXD2B

NCBI Official Name

SH3 and PX domain-containing protein 2B

NCBI Organism

Homo sapiens

Background Reference 01

Hishida T., et al.FEBS J. 275:5576-5588 (2008) .

Background Reference 02

Lanyi A., et al.Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.

Background Reference 03

Schmutz J., et al.Nature 431:268-274 (2004) .

Background Reference 04

Nagase T., et al.DNA Res. 7:65-73 (2000) .

Other Product Names

SH3 and PX domain-containing protein 2B, Adapter protein HOFI, Factor for adipocyte differentiation 49, Tyrosine kinase substrate with four SH3 domains, SH3PXD2B, FAD49, KIAA1295, TKS4