MGAT4A Antibody

Product Specifications

Background

Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N- linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells.

NCBI Gene ID

11320

Swiss Prot

Q9UM21

Accession Number

Q9UM21

Host

Rabbit

Reactivity

Mouse

Immunogen

This MGAT4A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 70-102 amino acids from human MGAT4A.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Chicken

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

62 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:2000

Symbol

MGAT4A

NCBI Official Name

Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A

NCBI Organism

Homo sapiens

Background Reference 01

Yoshida A., et al.Glycobiology 9:303-310 (1999) .

Background Reference 02

Ota T., et al.Nat. Genet. 36:40-45 (2004) .

Background Reference 03

Hillier L.W., et al.Nature 434:724-731 (2005) .

Background Reference 04

Mural R.J., et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

Other Product Names

Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A, 2.4.1.145, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVa, GlcNAc-T IVa, GnT-IVa, N-acetylglucosaminyltransferase IVa, UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVa, Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A soluble form, MGAT4A