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KLB Antibody

Product Specifications

Background

Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity) .

NCBI Gene ID

152831

Swiss Prot

Q86Z14

Accession Number

Q86Z14

Host

Rabbit

Reactivity

Human

Immunogen

This KLB antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1-29 amino acids from human KLB.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

120 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:2000

Symbol

KLB

NCBI Official Name

Beta-klotho

NCBI Organism

Homo sapiens

Background Reference 01

Hayashi A., et al.Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases.

Background Reference 02

Wu X., et al.J. Biol. Chem. 283:33304-33309 (2008) .

Background Reference 03

Micanovic R., et al.J. Cell. Physiol. 219:227-234 (2009) .

Other Product Names

Beta-klotho, BKL, BetaKlotho, Klotho beta-like protein, KLB

Tested Applications

WB

Protein ID

74750586

Physical Properties

Liquid

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