F7 Antibody

Product Specifications

Background

Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.

NCBI Gene ID

2155

Swiss Prot

P08709

Accession Number

P08709

Host

Rabbit

Reactivity

Human

Immunogen

This F7 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 302-332 amino acids from human F7.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

52 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:2000

Symbol

NCBI Official Name

Coagulation factor VII

NCBI Organism

Homo sapiens

Background Reference 01

Hagen F.S., et al.Proc. Natl. Acad. Sci. U.S.A. 83:2412-2416 (1986) .

Background Reference 02

O'Hara P.J., et al.Proc. Natl. Acad. Sci. U.S.A. 84:5158-5162 (1987) .

Background Reference 03

Sabater-Lleal M., et al.Hum. Genet. 118:741-751 (2006) .

Background Reference 04

Soria J.M., et al.Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.

Other Product Names

Coagulation factor VII, 3.4.21.21, Proconvertin, Serum prothrombin conversion accelerator, SPCA, Eptacog alfa, Factor VII light chain, Factor VII heavy chain, F7