SLC5A8 Antibody

Product Specifications

Background

Acts as an electrogenic sodium (Na (+) ) and chloride (Cl-) -dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D- hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na (+) :substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D- lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na (+) gradient and hence contribute to the maintenance of the energy status and function of neurons.

NCBI Gene ID

160728

Swiss Prot

Q8N695

Accession Number

Q8N695

Host

Rabbit

Reactivity

Human

Immunogen

This SLC5A8 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 579-609 amino acids from the human SLC5A8.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Obesity, Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

67 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

SLC5A8

NCBI Official Name

Sodium-coupled monocarboxylate transporter 1

NCBI Organism

Homo sapiens

Background Reference 01

Rodriguez A.-M., et al.J. Clin. Endocrinol. Metab. 87:3500-3503 (2002) .

Background Reference 02

Li H., et al.Proc. Natl. Acad. Sci. U.S.A. 100:8412-8417 (2003) .

Background Reference 03

Miyauchi S., et al.J. Biol. Chem. 279:13293-13296 (2004) .

Background Reference 04

Coady M.J., et al.J. Physiol. (Lond.) 557:719-731 (2004) .

Other Product Names

Sodium-coupled monocarboxylate transporter 1, Apical iodide transporter, Electrogenic sodium monocarboxylate cotransporter, Sodium iodide-related cotransporter, Solute carrier family 5 member 8, SLC5A8 {ECO:0000312|EMBL:AAP46193.1}