MGAT4B Antibody

Product Specifications

Background

Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N- linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Has lower affinities for donors or acceptors than MGAT4A, suggesting that, under physiological conditions, it is not the main contributor in N- glycan biosynthesis.

NCBI Gene ID

11282

Swiss Prot

Q9UQ53

Accession Number

Q9UQ53

Host

Rabbit

Reactivity

Human

Immunogen

This MGAT4B antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 32-62 amino acids from human MGAT4B.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

63 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:2000

Symbol

MGAT4B

NCBI Official Name

Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B

NCBI Organism

Homo sapiens

Background Reference 01

Yoshida A., et al.Glycoconj. J. 15:1115-1123 (1998) .

Background Reference 02

Clark H.F., et al.Genome Res. 13:2265-2270 (2003) .

Background Reference 03

Ota T., et al.Nat. Genet. 36:40-45 (2004) .

Background Reference 04

Schmutz J., et al.Nature 431:268-274 (2004) .

Other Product Names

Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B, 2.4.1.145, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVb, GlcNAc-T IVb, GnT-IVb, N-acetylglucosaminyltransferase IVb, UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVb, MGAT4B