ZNF238 Antibody

Product Specifications

Background

Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. Specifically binds the consensus DNA sequence 5'- [AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. May also play a role in the organization of chromosomes in the nucleus.

NCBI Gene ID

10472

Swiss Prot

Q99592

Accession Number

Q99592

Host

Rabbit

Reactivity

Mouse

Immunogen

This ZNF238 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 318-331 amino acids from human ZNF238.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

58 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:2000

Symbol

ZBTB18

NCBI Official Name

Zinc finger and BTB domain-containing protein 18

NCBI Organism

Homo sapiens

Background Reference 01

Becker K.G., et al.Hum. Mol. Genet. 4:685-691 (1995) .

Background Reference 02

Aoki K., et al.J. Biol. Chem. 273:26698-26704 (1998) .

Background Reference 03

Meng G., et al.Gene 242:59-64 (2000) .

Background Reference 04

Ota T., et al.Nat. Genet. 36:40-45 (2004) .

Other Product Names

Zinc finger and BTB domain-containing protein 18, 58 kDa repressor protein, Transcriptional repressor RP58, Translin-associated zinc finger protein 1, TAZ-1, Zinc finger protein 238, Zinc finger protein C2H2-171, ZBTB18, RP58, TAZ1, ZNF238