HRD1 Antibody

Product Specifications

Background

HRD1 encodes a protein involved in endoplasmic reticulum (ER) -associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. This gene and the mitochondrial ribosomal protein L49 gene use in their respective 3' UTRs some of the same genomic sequence.

NCBI Gene ID

84447

Swiss Prot

Q86TM6

Accession Number

Q86TM6

Host

Rabbit

Reactivity

Human

Immunogen

This HRD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 106-138 amino acids from the N-terminal region of human HRD1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Xenopus

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

68 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

SYVN1

NCBI Official Name

E3 ubiquitin-protein ligase synoviolin

NCBI Organism

Homo sapiens

Background Reference 01

Bernardi, K.M., et al. Mol. Biol. Cell 21 (1) :140-151 (2010) Ballar, P., et al. Int. J. Biochem. Cell Biol. 42 (1) :167-173 (2010) Shmueli, A., et al. Biochem. Biophys. Res. Commun. 390 (3) :758-762 (2009)