Ataxin3 Antibody

Product Specifications

Background

Machado-Joseph disease is an autosomal dominant neurologic disorder, and is now known to be the same as previously described spinocerebellar ataxia-3. MJD protein (Ataxin-3) contains (CAG) n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is the cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. This protein interacts with key regulators (CBP, p300 and PCAF) of transcription and represses transcription, and also acts as a histone-binding protein that regulates transcription. MJD is a deubiquitinating enzyme.

NCBI Gene ID

4287

Swiss Prot

P54252

Accession Number

P54252

Host

Rabbit

Reactivity

Human

Immunogen

This Ataxin3 (MJD) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 29-59 amino acids from the N-terminal region of human Ataxin3 (MJD) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

42 kDa

Fragment

Rabbit Ig

Applications Notes

For IHC-P starting dilution is: 1:50~100

Symbol

ATXN3

NCBI Official Name

Ataxin-3

NCBI Organism

Homo sapiens

Background Reference 01

Albrecht, M., et al., Eur. J. Biochem. 271 (15) :3155-3170 (2004) .

Background Reference 02

Michlewski, G., et al., J. Mol. Biol. 340 (4) :665-679 (2004) .

Background Reference 03

Li, Y., et al., Ann. Neurol. 56 (1) :124-129 (2004) .

Background Reference 04

Beuckmann, C.T., et al., J. Neurosci. 24 (18) :4469-4477 (2004) .

Other Product Names

Ataxin-3, Machado-Joseph disease protein 1, Spinocerebellar ataxia type 3 protein, ATXN3, ATX3, MJD, MJD1, SCA3

Tested Applications

IHC-P

Protein ID

290457685

Physical Properties

Liquid

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