Ubiquilin1 Antibody
Product Specifications
Background
PLIC1 is an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and is found in lesions associated with Alzheimer's and Parkinson's disease.
NCBI Gene ID
29979
Swiss Prot
Q9UMX0
Accession Number
Q9UMX0
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This Ubiquilin1 (PLIC1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-49 amino acids from the N-terminal region of human Ubiquilin1 (PLIC1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
63 kDa
Fragment
Rabbit Ig
Symbol
UBQLN1
NCBI Official Name
Ubiquilin-1
NCBI Organism
Homo sapiens
Background Reference 01
Gao, L., et al., J. Virol. 77 (7) :4149-4159 (2003) .
Background Reference 02
Kleijnen, M.F., et al., Mol. Cell 6 (2) :409-419 (2000) .
Background Reference 03
Mah, A.L., et al., J. Cell Biol. 151 (4) :847-862 (2000) .
Background Reference 04
Hanaoka, E., et al., J. Hum. Genet. 45 (3) :188-191 (2000) .
Other Product Names
Ubiquilin-1, Protein linking IAP with cytoskeleton 1, PLIC-1, hPLIC-1, UBQLN1, DA41, PLIC1
Tested Applications
WB, IHC-P
Protein ID
48475013
Physical Properties
Liquid
Frequently Asked Questions
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