TSG101 Antibody

Product Specifications

Background

TSG101 belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression.

NCBI Gene ID

7251

Swiss Prot

Q99816

Accession Number

Q99816

Host

Rabbit

Reactivity

Human

Immunogen

This TSG101 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 340-370 amino acids from the C-terminal region of human TSG101.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

44 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

TSG101

NCBI Official Name

Tumor susceptibility gene 101 protein

NCBI Organism

Homo sapiens

Background Reference 01

Favre, M., et al., J. Acquir. Immune Defic. Syndr. 34 (2) :127-133 (2003) .

Background Reference 02

Lu, Q., et al., Proc. Natl. Acad. Sci. U.S.A. 100 (13) :7626-7631 (2003) .

Background Reference 03

Goila-Gaur, R., et al., J. Virol. 77 (11) :6507-6519 (2003) .

Background Reference 04

Blanco, S., et al., FEMS Microbiol. Lett. 221 (2) :151-154 (2003) .

Other Product Names

Tumor susceptibility gene 101 protein, ESCRT-I complex subunit TSG101, TSG101

Tested Applications

Protein ID

9789790

Physical Properties

Liquid

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