UCHL1 Antibody

Product Specifications

Background

UCHL1 is a member of a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to generate the ubiquitin monomer. Expression of UCHL1 is highly specific to neurons and to cells of the diffuse neuroendocrine system and their tumors. It is present in all neurons (Doran et al., 1983 [PubMed 6343558]) .

NCBI Gene ID

7345

Swiss Prot

P09936

Accession Number

P09936

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

This UCHL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 187-216 amino acids from the C-terminal region of human UCHL1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Neuroscience

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Monkey, Pig, Bovine

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

25 kDa

Fragment

Rabbit Ig

Symbol

UCHL1

NCBI Official Name

Ubiquitin carboxyl-terminal hydrolase isozyme L1

NCBI Organism

Homo sapiens

Background Reference 01

Maraganore, D.M., et al., Mov Disord 18 (6) :631-636 (2003) . Nishikawa, K., et al., Biochem. Biophys. Res. Commun. 304 (1) :176-183 (2003) . Liu, Y., et al., Cell 111 (2) :209-218 (2002) . Caballero, O.L., et al., Oncogene 21 (19) :3003-3010 (2002) . Saigoh, K., et al., Nat. Genet. 23 (1) :47-51 (1999) .