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HIP2 Antibody

Product Specifications

Background

HIP2 belongs to the ubiquitin-conjugating enzyme family. It binds selectively to a large region at the N terminus of huntingtin. This interaction is not influenced by the length of the huntingtin polyglutamine tract. This protein has been implicated in the degradation of huntingtin and suppression of apoptosis.

NCBI Gene ID

3093

Swiss Prot

P61086

Accession Number

P61086

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This HIP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 109-139 amino acids from the Central region of human HIP2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Neuroscience

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=61-078

Calculated Molecular Weight

22 kDa

Fragment

Rabbit Ig

Symbol

UBE2K

NCBI Official Name

Ubiquitin-conjugating enzyme E2 K

NCBI Organism

Homo sapiens

Background Reference 01

Furukawa, Y., et al., Electrophoresis 21 (2) :338-346 (2000) .

Background Reference 02

Kikuchi, J., et al., Arterioscler. Thromb. Vasc. Biol. 20 (1) :128-134 (2000) .

Background Reference 03

Petersen, A., et al., Exp. Neurol. 157 (1) :1-18 (1999) .

Background Reference 04

Kalchman, M.A., et al., J. Biol. Chem. 271 (32) :19385-19394 (1996) .

Other Product Names

Ubiquitin-conjugating enzyme E2 K, Huntingtin-interacting protein 2, HIP-2, Ubiquitin carrier protein, Ubiquitin-conjugating enzyme E2-25 kDa, Ubiquitin-conjugating enzyme E2 (25K), Ubiquitin-conjugating enzyme E2-25K, Ubiquitin-protein ligase, UBE2K, HIP2, LIG

Tested Applications

WB, IHC-P, IF

Protein ID

46577658

Physical Properties

Liquid

Curated Selection

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