E1 Ubiquitin Antibody
Product Specifications
Background
UBE1 catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternative splicing results in 2 transcript variants encoding the same protein, but with different 5' UTR.
NCBI Gene ID
7317
Swiss Prot
P22314
Accession Number
P22314
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This E1 Ubiquitin (UBE1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1026-1058 amino acids from the C-terminal region of human E1 Ubiquitin (UBE1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Rabbit, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
118 kDa
Fragment
Rabbit Ig
Symbol
UBA1
NCBI Official Name
Ubiquitin-like modifier-activating enzyme 1
NCBI Organism
Homo sapiens
Background Reference 01
Ayusawa, D., et al., Cell Struct. Funct. 17 (2) :113-122 (1992) . Handley, P.M., et al., Proc. Natl. Acad. Sci. U.S.A. 88 (1) :258-262 (1991) . Kudo, M., et al., Exp. Cell Res. 192 (1) :110-117 (1991) . Zacksenhaus, E., et al., Cytogenet. Cell Genet. 53 (1) :20-22 (1990) . Zacksenhaus, E., et al., EMBO J. 9 (9) :2923-2929 (1990) .
Other Product Names
Ubiquitin-like modifier-activating enzyme 1, Protein A1S9, Ubiquitin-activating enzyme E1, UBA1, A1S9T, UBE1
Tested Applications
WB, IHC-P
Protein ID
24418865
Physical Properties
Liquid
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