GDF5 Antibody
Product Specifications
Background
GDF5 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type; brachydactyly, type C; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development.
NCBI Gene ID
8200
Swiss Prot
P43026
Accession Number
P43026
Host
Rabbit
Reactivity
Human
Immunogen
This GDF5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-41 amino acids from the N-terminal region of human GDF5.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=61-070
Calculated Molecular Weight
55 kDa
Fragment
Rabbit Ig
Symbol
GDF5
NCBI Official Name
Growth/differentiation factor 5
NCBI Organism
Homo sapiens
Background Reference 01
Kusafuka, K., et al., Virchows Arch. 442 (5) :482-490 (2003) .
Background Reference 02
Faiyaz-Ul-Haque, M., et al., Am. J. Med. Genet. 111 (1) :31-37 (2002) .
Background Reference 03
Everman, D.B., et al., Am. J. Med. Genet. 112 (3) :291-296 (2002) .
Background Reference 04
Faiyaz-Ul-Haque, M., et al., Clin. Genet. 61 (6) :454-458 (2002) .
Other Product Names
Growth/differentiation factor 5, GDF-5, Bone morphogenetic protein 14, BMP-14, Cartilage-derived morphogenetic protein 1, CDMP-1, Lipopolysaccharide-associated protein 4, LAP-4, LPS-associated protein 4, Radotermin, GDF5, BMP14, CDMP1
Tested Applications
WB, IHC-P
Protein ID
20141384
Physical Properties
Liquid
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