GDF5 Antibody

Product Specifications

Background

GDF5 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type; brachydactyly, type C; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development.

NCBI Gene ID

8200

Swiss Prot

P43026

Accession Number

P43026

Host

Rabbit

Reactivity

Human

Immunogen

This GDF5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-41 amino acids from the N-terminal region of human GDF5.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

55 kDa

Fragment

Rabbit Ig

Symbol

GDF5

NCBI Official Name

Growth/differentiation factor 5

NCBI Organism

Homo sapiens

Background Reference 01

Kusafuka, K., et al., Virchows Arch. 442 (5) :482-490 (2003) .

Background Reference 02

Faiyaz-Ul-Haque, M., et al., Am. J. Med. Genet. 111 (1) :31-37 (2002) .

Background Reference 03

Everman, D.B., et al., Am. J. Med. Genet. 112 (3) :291-296 (2002) .

Background Reference 04

Faiyaz-Ul-Haque, M., et al., Clin. Genet. 61 (6) :454-458 (2002) .

Other Product Names

Growth/differentiation factor 5, GDF-5, Bone morphogenetic protein 14, BMP-14, Cartilage-derived morphogenetic protein 1, CDMP-1, Lipopolysaccharide-associated protein 4, LAP-4, LPS-associated protein 4, Radotermin, GDF5, BMP14, CDMP1