CRX Antibody

Product Specifications

Background

Binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, e.g. NRL and RX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors.

NCBI Gene ID

1406

Swiss Prot

O43186

Accession Number

O43186

Host

Rabbit

Reactivity

Human

Immunogen

This CRX antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 294-297 amino acids from the C-terminal region of human CRX.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Neuroscience

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

32 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

CRX

NCBI Official Name

Cone-rod homeobox protein

NCBI Organism

Homo sapiens

Background Reference 01

Freund C.L., et al.Cell 91:543-553 (1997) .

Background Reference 02

Kalnine N., et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.

Background Reference 03

Grimwood J., et al.Nature 428:529-535 (2004) .

Background Reference 04

Roni V., et al.BMC Genomics 8:42-42 (2007) .

Other Product Names

Cone-rod homeobox protein, CRX, CORD2

Tested Applications

Physical Properties

Liquid

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