CHRNA9 Antibody
Product Specifications
Background
Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion.
NCBI Gene ID
55584
Swiss Prot
Q9UGM1
Accession Number
Q9UGM1
Host
Rabbit
Reactivity
Human
Immunogen
This CHRNA9 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 8-42 amino acids from the N-terminal region of human CHRNA9.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
55 kDa
Fragment
Rabbit Ig
Symbol
CHRNA9
NCBI Official Name
Neuronal acetylcholine receptor subunit alpha-9
NCBI Organism
Homo sapiens
Background Reference 01
Sgard F., et al.Mol. Pharmacol. 61:150-159 (2002) .
Background Reference 02
Lustig L.R., et al.Cytogenet. Genome Res. 98:154-159 (2002) .
Background Reference 03
Hillier L.W., et al.Nature 434:724-731 (2005) .
Background Reference 04
Nguyen V.T., et al.Am. J. Pathol. 157:1377-1391 (2000) .
Other Product Names
Neuronal acetylcholine receptor subunit alpha-9, Nicotinic acetylcholine receptor subunit alpha-9, NACHR alpha-9, CHRNA9, NACHRA9
Tested Applications
WB, Flow
Protein ID
308153406
Physical Properties
Liquid
Frequently Asked Questions
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