FCGR3B Antibody

Product Specifications

Background

Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.

NCBI Gene ID

2215

Swiss Prot

O75015

Accession Number

O75015

Host

Rabbit

Reactivity

Human

Immunogen

This FCGR3B antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 12-47 amino acids from the N-terminal region of human FCGR3B.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

26 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

FCGR3B

NCBI Official Name

Low affinity immunoglobulin gamma Fc region receptor III-B

NCBI Organism

Homo sapiens

Background Reference 01

Ravetch J.V., et al.J. Exp. Med. 170:481-497 (1989) .

Background Reference 02

Simmons D., et al.Nature 333:568-570 (1988) .

Background Reference 03

Simmons D., et al.Nature 340:662-662 (1989) .

Background Reference 04

Peltz G.A., et al.Proc. Natl. Acad. Sci. U.S.A. 86:1013-1017 (1989) .

Other Product Names

Low affinity immunoglobulin gamma Fc region receptor III-B, Fc-gamma RIII-beta, Fc-gamma RIII, Fc-gamma RIIIb, FcRIII, FcRIIIb, FcR-10, IgG Fc receptor III-1, CD16b, FCGR3B, CD16B, FCG3, FCGR3, IGFR3