IL4R Antibody

Product Specifications

Background

Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.

NCBI Gene ID

3566

Swiss Prot

P24394

Accession Number

P24394

Host

Rabbit

Reactivity

Human

Immunogen

This IL4R antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 677-691 amino acids from the C-terminal region of human IL4R.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Immunology

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

90 kDa

Fragment

Rabbit Ig

Symbol

IL4R

NCBI Official Name

Interleukin-4 receptor subunit alpha

NCBI Organism

Homo sapiens

Background Reference 01

Idzerda R.L., et al.J. Exp. Med. 171:861-873 (1990) .

Background Reference 02

Galizzi J.-P., et al.Int. Immunol. 2:669-675 (1990) .

Background Reference 03

Kruse S., et al.Int. Immunol. 11:1965-1970 (1999) .

Background Reference 04

Loftus B.J., et al.Genomics 60:295-308 (1999) .

Other Product Names

Interleukin-4 receptor subunit alpha, IL-4 receptor subunit alpha, IL-4R subunit alpha, IL-4R-alpha, IL-4RA, CD124, Soluble interleukin-4 receptor subunit alpha, Soluble IL-4 receptor subunit alpha, Soluble IL-4R-alpha, sIL4Ralpha/prot, IL-4-binding protein, IL4-BP, IL4R, IL4RA