ACVRL1 Antibody
Product Specifications
Background
Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.
NCBI Gene ID
94
Swiss Prot
P37023
Accession Number
P37023
Host
Rabbit
Reactivity
Human
Immunogen
This ACVRL1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 11-44amino acids from the N-terminal region of human ACVRL1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
56 kDa
Fragment
Rabbit Ig
Symbol
ACVRL1
NCBI Official Name
Serine/threonine-protein kinase receptor R3
NCBI Organism
Homo sapiens
Background Reference 01
Ten Dijke P., et al.Oncogene 8:2879-2887 (1993) .
Background Reference 02
Attisano L., et al.Cell 75:671-680 (1993) .
Background Reference 03
Berg J.N., et al.Am. J. Hum. Genet. 61:60-67 (1997) .
Background Reference 04
Scherer S.E., et al.Nature 440:346-351 (2006) .
Other Product Names
Serine/threonine-protein kinase receptor R3, SKR3, Activin receptor-like kinase 1, ALK-1, TGF-B superfamily receptor type I, TSR-I, ACVRL1, ACVRLK1, ALK1
Tested Applications
WB, IHC-P
Protein ID
3915750
Physical Properties
Liquid
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