ECE2 Antibody

Product Specifications

Background

Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit beta-amyloid peptide accumulation in brain. May also have methyltransferase activity.

NCBI Gene ID

9718

Swiss Prot

O60344

Accession Number

O60344

Host

Rabbit

Reactivity

Human

Immunogen

This ECE2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 551-579 amino acids from the Central region of human ECE2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

100 kDa

Fragment

Rabbit Ig

Symbol

ECE2

NCBI Official Name

Endothelin-converting enzyme 2

NCBI Organism

Homo sapiens

Background Reference 01

Lorenzo M.-N., et al. Biochim. Biophys. Acta 1522:46-52 (2001) .

Background Reference 02

Funke-Kaiser H., et al. Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.

Background Reference 03

Nagase T., et al. DNA Res. 5:31-39 (1998) .

Background Reference 04

Clark H.F., et al. Genome Res. 13:2265-2270 (2003) .

Other Product Names

Endothelin-converting enzyme 2, ECE-2, Methyltransferase-like region, 211-, Endothelin-converting enzyme 2 region, ECE2, KIAA0604

Tested Applications

WB, IHC-P

Physical Properties

Liquid

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