CUL4B Antibody
Product Specifications
Background
This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
NCBI Gene ID
8450
Swiss Prot
Q13620
Accession Number
Q13620
Host
Rabbit
Reactivity
Human
Immunogen
This CUL4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 250-278 amino acids from the Central region of human CUL4B.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
104 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
CUL4B
NCBI Official Name
Cullin-4B
NCBI Organism
Homo sapiens
Background Reference 01
Aggarwal, P., et al. Cancer Cell 18 (4) :329-340 (2010)
Background Reference 02
Abbas, T., et al. Mol. Cell 40 (1) :9-21 (2010)
Background Reference 03
Kerzendorfer, C., et al. Hum. Mol. Genet. 19 (7) :1324-1334 (2010)
Background Reference 04
Gascoin-Lachambre, G., et al. Placenta 31 (2) :151-157 (2010)
Other Product Names
Cullin-4B, CUL-4B, CUL4B, KIAA0695
Tested Applications
WB
Protein ID
296439468
Physical Properties
Liquid
Curated Selection
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