NeuroD1 Antibody

NeuroD1 is a transcriptional activator that acts as a differentiation factor during neurogenesis. It has been demonstrated to bind to the insulin gene E-box. Efficient DNA binding requires dimerization with another basic helix-loop-helix (bHLH) protein. Defects in NEUROD1 are a cause of maturity onset diabetes of the young type VI (MODY6) . MODY6 is a form of non-insulin-dependent diabetes mellitus characterized by an autosomal dominant mode of inheritance, onset during young adulthood and a primary defect in insulin secretion.

This NeuroD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 318-348 amino acids from the C-terminal region of human NeuroD1.

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99 (26) :16899-16903 (2002) . Miyachi, T., et al., Brain Res. Mol. Brain Res. 69 (2) :223-231 (1999) . Malecki, M.T., et al., Nat. Genet. 23 (3) :323-328 (1999) . Acharya, H.R., et al., Biochem. Biophys. Res. Commun. 233 (2) :459-463 (1997) . Yokoyama, M., et al., Brain Res. Mol. Brain Res. 42 (1) :135-139 (1996) .