NeuroD1 Antibody
Product Specifications
Background
NeuroD1 is a transcriptional activator that acts as a differentiation factor during neurogenesis. It has been demonstrated to bind to the insulin gene E-box. Efficient DNA binding requires dimerization with another basic helix-loop-helix (bHLH) protein. Defects in NEUROD1 are a cause of maturity onset diabetes of the young type VI (MODY6) . MODY6 is a form of non-insulin-dependent diabetes mellitus characterized by an autosomal dominant mode of inheritance, onset during young adulthood and a primary defect in insulin secretion.
NCBI Gene ID
4760
Swiss Prot
Q13562
Accession Number
Q13562
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
This NeuroD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 318-348 amino acids from the C-terminal region of human NeuroD1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Neuroscience
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=60-933
Calculated Molecular Weight
40 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
NEUROD1
NCBI Official Name
Neurogenic differentiation factor 1
NCBI Organism
Homo sapiens
Background Reference 01
Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99 (26) :16899-16903 (2002) . Miyachi, T., et al., Brain Res. Mol. Brain Res. 69 (2) :223-231 (1999) . Malecki, M.T., et al., Nat. Genet. 23 (3) :323-328 (1999) . Acharya, H.R., et al., Biochem. Biophys. Res. Commun. 233 (2) :459-463 (1997) . Yokoyama, M., et al., Brain Res. Mol. Brain Res. 42 (1) :135-139 (1996) .
Other Product Names
Neurogenic differentiation factor 1, NeuroD, NeuroD1, Class A basic helix-loop-helix protein 3, bHLHa3, NEUROD1, BHLHA3, NEUROD
Tested Applications
WB
Protein ID
311033428
Physical Properties
Liquid
Curated Selection
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