NeuroD1 Antibody

Product Specifications

Background

NeuroD1 is a transcriptional activator that acts as a differentiation factor during neurogenesis. It has been demonstrated to bind to the insulin gene E-box. Efficient DNA binding requires dimerization with another basic helix-loop-helix (bHLH) protein. Defects in NEUROD1 are a cause of maturity onset diabetes of the young type VI (MODY6) . MODY6 is a form of non-insulin-dependent diabetes mellitus characterized by an autosomal dominant mode of inheritance, onset during young adulthood and a primary defect in insulin secretion.

NCBI Gene ID

4760

Swiss Prot

Q13562

Accession Number

Q13562

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

This NeuroD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 318-348 amino acids from the C-terminal region of human NeuroD1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Neuroscience

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

40 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

NEUROD1

NCBI Official Name

Neurogenic differentiation factor 1

NCBI Organism

Homo sapiens

Background Reference 01

Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99 (26) :16899-16903 (2002) . Miyachi, T., et al., Brain Res. Mol. Brain Res. 69 (2) :223-231 (1999) . Malecki, M.T., et al., Nat. Genet. 23 (3) :323-328 (1999) . Acharya, H.R., et al., Biochem. Biophys. Res. Commun. 233 (2) :459-463 (1997) . Yokoyama, M., et al., Brain Res. Mol. Brain Res. 42 (1) :135-139 (1996) .